Cellular Phenotyping Platform
Dr. Claire Conche
Aim
The Cellular Phenotyping Platform (formerly known as the Immunomonitoring Platform) provides advanced tools and methodologies to investigate immune responses, with a special focus on solid cancers.
Our expertise includes deep immunophenotyping using high-parameter (>30) spectral flow cytometry to analyze patient samples.
In addition, we offer cell sorting capabilities, enabling the isolation of specific immune cell subsets for downstream applications.
We have extensive experience in developing customized in vitro, ex vivo, and in vivo assays tailored to study the activities and functions of immune cells.
Do not hesitate to contact us for further information.
Cellular Phenotyping Platform
Dr. Claire Conche
privat
[since 2023] Head of the Immunomonitoring Platform, HI-TRON Mainz
[2017 - 2023] Senior Postdoctoral Fellow in Cancer Immunotherapies at the Georg Speyer Haus Frankfurt am Main
[2010 - 2015] Postdoctoral Fellow on T cell biology at The Scripps Research Institute, USA.
[2005 - 2009] Ph.D. Student on TCR signalling at the Cochin Institute, France
HI-TRON Mainz DKFZ
Immunomonitoring Platform
Obere Zahlbacherstr. 63
Building 911
55131 Mainz
Collaborations
We maintain strong collaborations with the research divisions at HI-TRON and have also built valuable partnerships with research groups at the University Medical Center Mainz.
Selected publications of C.Conche
- Conche C, Finkelmeier F, Pesic M, Nicolas AM, Bottger T W, Kennel K B, Denk D, Ceteci F, Mohs K, Engel E, Canli O, Dabiri Y, Peiffer KH, Zeuzem S, Salinas G, Longerich T, Yang H, Greten FR. Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade. Gut. 2023;72(9):1774-1782
- Denk D, Petrocelli V, Conche, C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux PA, Rinsch C, Greten FR. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity. 2022;55(11):2059-2073
- Westernberg L, Conche C, Huang YH, Rigaud S, Deng Y, Siegemund S, Mukherjee S, Nosaka L, Das J, Sauer K. Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent. eLife. 2016;5:e10786
- Siegemund S, Rigaud S, Conche C, Broaten B, Schaffer L, Westernberg L, Head SR, Sauer K. IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice. Blood. 2015;125:2786-2797
Platform News
10/2024: The platform presented its latest data on “Unlocking the Spectrum: Advances In Multiplexing And Custom Assays With Spectral Flow Cytometry” at the Munich Cytek Days
12/2023: The Cytek Aurora, our new spectral flow cytometer arrived.
Gallery
Created with BioRender.com
privat
privat
