Cellular Phenotyping Platform
Dr. Claire Conche
Aim
The Cellular Phenotyping Platform (formerly known as the Immunomonitoring Platform) provides advanced tools and methodologies to investigate immune responses, with a special focus on solid cancers.
Our expertise includes deep immunophenotyping using high-parameter (>30) spectral flow cytometry to analyze patient samples. We also offer advanced multi-modal microscopy, including confocal, multi-photon, second-harmonic generation, and coherent Raman scattering for
high-resolution fluorescence and label-free imaging of fixed and live samples. Together, these complementary approaches provide an integrated framework for studying immune cell composition, spatial organization, and function.
In addition, we offer cell sorting capabilities, enabling the isolation of specific immune cell subsets for downstream applications.
We have extensive experience in developing customized in vitro, ex vivo, and in vivo assays as well as imaging workflows tailored to study the activities and functions of immune cells.
Do not hesitate to contact us for further information.
Cellular Phenotyping Platform
Dr. Claire Conche
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[since 2023] Head of the Cellular Phenotyping Platform, HI-TRON Mainz
[2017 - 2023] Senior Postdoctoral Fellow in Cancer Immunotherapies at the Georg Speyer Haus Frankfurt am Main
[2010 - 2015] Postdoctoral Fellow on T cell biology at The Scripps Research Institute, USA.
[2005 - 2009] Ph.D. Student on TCR signalling at the Cochin Institute, France
HI-TRON Mainz DKFZ
Immunomonitoring Platform
Obere Zahlbacherstr. 63
Building 911
55131 Mainz
Team
Dr. Cong Xu
Imaging staff scientist and HI-TRON lab manager.
Collaborations
We maintain strong collaborations with the research divisions at HI-TRON and have also built valuable partnerships with research groups at the University Medical Center Mainz.
Selected publications
- Raimondo MG, Mohammadian H, Angeli MR, Alivernini S, Fedorchenko V, Huang K, Demmler R, Rhein P, Xu C, Li Y-N, Micheroli R, Winter Z, Rigau AR, Anchang CG, Soare A, Luber M, zabinsky H, Chang J, Günther C, Fearon U, Veale DJ, Ciccia F, Rech J, Sticherling M, Bäuerle T, Distler JHW, Kurowska-Stolarska MS, Mack M, Ekici AB, Croft AP, Distler O, Maric HM, Ospelt, Cañete JD, D’Agostino A, Schett G, Rauber S, Ramming A. Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to joints. Nature Immunology. 2026; 27, 35–47
- Kumar R, Das S, Minka W, Reiter C, Pereira R, Fuhrmann D, Schneider R, Seshire A, Reusch C, Conche C, Imkeller K, Pajevic PD, Krause DS. The role of the extracellular matrix protein SPOCK2 for bone physiology and hematopoiesis. Bone. 2025; Volume 198, 117539
- Denk D*, Ramakrishnan M*, Conche C*, Pallangyo C, Pesic M, Ceteci F, Kennel K B, Kirisözü A C, Engel E, Mohs K, Ritter B, Pardo A M, Özkurt E, Hildebrand F, Waisman A, Arkan M C, Greten F R. IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis. Immunity. 2025. *These authors contributed equally
- Koh BI, Mohanakrishnan V, Jeong HW, Park H, Kruse K, Choi YJ, Nieminen-Kelhä M, Kumar R, Pereira RS, Adams S, Lee HJ, Bixel MG, Vajkoczy P, Krause DS, Adams R H. Adult skull bone marrow is an expanding and resilient haematopoietic reservoir. Nature. 2024; 636(8041):172-181
- Conche C, Finkelmeier F, Pesic M, Nicolas AM, Bottger T W, Kennel K B, Denk D, Ceteci F, Mohs K, Engel E, Canli O, Dabiri Y, Peiffer KH, Zeuzem S, Salinas G, Longerich T, Yang H, Greten FR. Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade. Gut. 2023;72(9):1774-1782
- Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux PA, Rinsch C, Greten FR. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity. 2022;55(11):2059-2073
- Pachowsky ML*, Raimondo MG*, Xu C*, Rauber S, Tascilar K, Labinsky H, Vogg M, Aziz Saad MS, Simon D, Rech J, Soare A, Braeuer L, Kleyer A, Schett G, Ramming A. A minimal-invasive method to retrieve and identify entheseal tissue from psoriatic arthritis patients. Annals of the Rheumatic Diseases. 2022; 81, 1131–1135 *These authors contributed equally
- Xu C, Dinh VV, Kruse K, Jeong HW, Watson EC, Adams S, Berkenfeld F, Stehling M, Rasouli SJ, Fan R, Chen R, Bedzhov I, Chen Q, Kato K, Pitulescu ME, Adams RH. Induction of osteogenesis by bone-targeted Notch activation. eLife. 2022; 11:e60183
Platform News
01/2026: A new member joins the platform: Lea Roth.
09/2025: Claire Conche presents some data on “Immunophenotyping In The Context Of Tumor Biology” at the Cytek User Group Meeting in Mainz
08/2025: The platform welcomes Dr. Cong Xu as Imaging Staff Scientist, who will be in charge of developing the Imaging portfolio of the platform
05/2025: New Publication: Kumar R, Das S, Minka W, Reiter C, Pereira R, Fuhrmann D, Schneider R, Seshire A, Reusch, C, Conche C, Imkeller K, Pajevic P D, Krause D S, The role of the extracellular matrix protein SPOCK2 for bone physiology and hematopoiesis. Bone. 2025; Volume 198, 117539.
10/2024: The platform presented its latest data on “Unlocking the Spectrum: Advances In Multiplexing And Custom Assays With Spectral Flow Cytometry” at the Munich Cytek Days
12/2023: The Cytek Aurora, our new spectral flow cytometer arrived.
Gallery
Created with BioRender.com
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