HI-TRON Mainz
« It's a perfect playground for scientists »
– M.V.
POSITION
Position: Postdoctoral Position - Immunopeptidomics and Tumor Immunobiology
POSITION
Postdoctoral Position
DEPARTMENT
Immunopeptidomics and Tumor Immunobiology
Immunoproteomics Unit
Code number
2024-0087
Earliest Possible Start Date
As soon as possible
Duration
2 years with possibility of prolongation
Application Deadline
03.04.2024
*The position can in principle be part-time.
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The Helmholtz Institute HI-TRON is a collaboration of the German Cancer Research Center (DKFZ) with the Research Institute for Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz (TRON gGmbH), the University Medical Center Mainz and the Johannes Gutenberg University Mainz. The goal of the partnership is to develop effective immunotherapies and to identify novel biomarkers for assessing the effectiveness of treatment.
For the Immunoproteomics Unit at the Helmholtz Institute in Mainz, we are seeking a postdoctoral researcher in the field of immunopeptidomics and tumor immunobiology to start as soon as possible.
The Immunoproteomics Unit aims to identify cancer-specific immunopeptides (MHC-ligands), antigens that can trigger the immune response, and potential targets for immunotherapy. To achieve this, we develop and implement LC-MS-based workflows to scrutinize the immunopeptidome in clinical, preclinical, and in vitro studies. The unit is headed by Prof. Stefan Tenzer and provide scientists with cutting-edge LC-MS immunopeptidomics infrastructure and expertise.
Job description
The project objective is to develop highly sensitiv workflows for sample preparation, LC-MS acquisition, and/or data analysis of immunopeptidomics experiments with a focus on neoepitope discovery in clinical studies. The scientist will contribute to collaboration projects from the study design to data analysis and interpretation, aiming to identify antigens in diverse cancer types in cell culture, tumor, and plasma samples. The specific goals will be adapted to the profile and interests of the selected applicant.
Main tasks:
- Planning and performing experiments and analyzing, interpreting, and reporting the results
- Communicating with collaboration partners and assisting in the coordination of students and technical staff
- Writing scientific publications and presenting at national and/or international conferences
- Optional: operating and maintaining LC-MS instruments (TimsTOF SCP, and/or the sample preparation robot (Beckman i7)The project objective is to develop high-throughput workflows for sample preparation, LC-MS acquisition, and/or data analysis of immunopeptidomics experiments. To facilitate clinical studies, the goal is to achieve the analysis of hundreds of samples per week. The scientist will contribute to collaboration projects from the study design to data analysis and interpretation, aiming to identify antigens in diverse types of cancer in cell culture, tumor, and plasma samples. The specific goals will be adapted to the profile and interests of the selected applicant.
Requirements
- Ph.D. with experience in biochemistry, biotechnology, analytical chemistry, bioinformatics, computational biology, or related fields; or M.Sc. with more than two years of experience
- Keen interest in bioanalytical chemistry, mass spectrometry, biochemistry, immunology, and/or oncology
- Previous experience with MS-based omics and related data analysis is an advantage, but not required
- Strong communication skills in English are required, knowledge of German is advantageous, but not required
- Creativity and strong analytical thinking
- Enthusiastic and motivated team player
We offer
Interesting versatile workplace
Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
Remuneration according to TV-L incl. occupational pension plan and capital-forming payments
30 days of vacation per year
Flexible working hours
Possibility of mobile work and part-time work
Family-friendly working environment, e.g. parent-child room, advisory services caring for elderly relatives
Sustainable travel to work: subsidized Germany job ticket
Develop your full potential: access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for your personal development to further develop your talents
Our Corporate Health Management Program offers a holistic approach to your well-being
Important notice
The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles may work at the DKFZ.
Contact
Dr. Stefan Tenzer
Phone +49 6131 176199
Please note that we do not accept applications submitted via email.
The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.
Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.
To apply for a position please use our online application portal (https://www.dkfz.de/en/stellenangebote/index.php) or via the button below.
We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.
